S-(-)-3-Hydroxy-gamma-butyrolactone

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S-(-)-3-Hydroxy-gamma-butyrolactone

S-(-)-3-Hydroxy-gamma-butyrolactone

S(-)-3-Hydroxy-γ- butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S(-)-Oxiracetam. s-3-Hydroxy-γ-butyrolactone can be deoxidized to S(-)-3-hydroxy-tetrahydrofurane which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer. It can also be used to produce S(-)-5-hydroxymethyl-oxazolin which is a new antibiotic drug. Besides, both S(-)-N-methyl-hydroxypyrrole and (R)-N-methyl-3-methylamino-pyrrole have important bioactivity, and they can be made from s-3-Hydroxy-γ-butyrolactone by simple reaction. Furthermore, s-3-Hydroxy-γ-butyrolactone can synthesize many natural products.

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Shanghai Openchem Co., Ltd.

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