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| Tacrolimus (FK506) |
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| Tacrolimus |
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| 104987-11-3 |
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Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug. Its main use is after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection.
It has similar immunosuppressive properties to cyclosporine, but is much more potent in equal volumes. Also like cyclosporine it has a wide range of adverse interactions, including that with grapefruit which increases plasma-tacrolimus concentration.
It has been used in a topical preparation in the treatment of severe atopic dermatitis, as have cyclosporine and azathioprine with much less success. It has also been used after bone marrow transplants and for severe refractory uveitis.
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White or off-white crystalline powder
Metling point: 127.0 ~ 129.0 degrees C
Assay: 98.0% ~ 102.%
Specific rotation [a] 20/D: -84.9 ~ -83.9 degrees
Related substance: not more than 2.0%
Water: not more than 3.0%
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